�Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universitat Munchen, scientists at the Helmholtz Zentrum Munchen suffer pinpointed a major factor for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Munchen.
Schematic representation of the high affinity sense organ for IgE. Variants within the gene encoding the alpha chain are associated with increased levels of IgE antibodies
The newly discovered FCER1A factor encodes the alpha chain of high affinity IgE receptor, which plays a major part in controlling allergic responses. The team of scientists led by Dr. Stephan Weidinger from the Technische Universit�t M�nchen and Dr. Thomas Illig from the Helmholtz Zentrum M�nchen ground that certain variations of the FCER1A gene decisively influence the production of immunoglobulin E (IgE) antibodies. IgE antibodies are a particular type of antibody that is normally ill-used to protect against parasites. In Western lifestyle countries with less contact, however, elevated IgE levels ar associated with allergic disorders.
In genetically susceptible individuals the immune system becomes slanted and produces IgE antibodies against harmless agents such as pollen, dust mites or animate being hair. These IgE antibodies then work in conjunction with sealed cells to get free of the allergens, a process that gives lift to the symptoms of allergy such as sensitised rhinitis (hay fever), atopic dermatitis or asthma.
"Most people with allergies are atopic - substance they take a familial tendency to develop allergies. To detect the genetical factors we examined the genomes of more than 10,000 adults and children from the whole of Germany" explained Stephan Weidinger.
Most of the persons examined for the report come from the population studies of the KORA (co-operative wellness research in the Augsburg region) research platform, which is light-emitting diode by Prof. Dr. H.-Erich Wichmann, the Director of the Institute of Epidemiology at the Helmholtz Zentrum M�nchen. The allergological examinations were carried by the Department for Dermatology and Allergy of the Technische Universit�t M�nchen headed by Prof. Dr. Dr. Johannes Ring.
Although in its early stages, the new cognition on the regulation of IgE production does suffer the potential difference to guide the development of new drugs.
Publication:
Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, et al. (2008) Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus. PLoS Genet 4(8): e1000166. interior: 10.1371/journal.pgen.1000166
http://www.plosgenetics.org/doi/pgen.1000166
Source: Heinz Joerg Haury
Helmholtz Zentrum M�nchen - German Research Center for Environmental Health
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Friday 29 August 2008
Saturday 9 August 2008
Nickel Creek
Artist: Nickel Creek
Genre(s):
Country
Discography:
Why Should The Fire Die?
Year:
Tracks: 14
This Side
Year:
Tracks: 13
Distinguished by their youth and eclecticist gustatory esthesis, Nickel Creek became a pipeline sense datum on the progressive bluegrass scene and in brief set up their appeal spreading beyond the genre's core audience. Guitarist Sean Watkins, fiddler Sara Watkins (his jr. sister), and mandolin/banjo/bouzouki musician Chris Thile number 1 started acting together in 1989, when all deuce-ace were preteens and taking medicine lessons in their native San Diego. They met spell observation the local band Bluegrass Etc., which put on weekly performances in a pizza sitting room. A bluegrass Region plugger liked the estimate of such a young band, and so Nickel Creek was formed, with Thile's fatherhood Scott connexion them on bass. Nickel Creek were regulars on the festival lap through most of the '90s, and during that time, Thile recorded iI solo albums, 1994's Leading Off... and 1997's Stealth Second. In 1998, with help from Alison Krauss, Nickel Creek landed a record conduct with the roots medical specialty label Sugar Hill. Krauss produced their self-titled debut album, which was released in 2000; with the kids ostensibly all right, Scott afterward retired from the ring. Though it was by all odds a bluegrass record, Atomic number 28 Creek boasted elements of classic, jazz, and rock 'n' roll & undulate both classical and alternative; naturally, the influence of progressive bluegrass Country figures like Krauss, Edgar Meyer, and Béla Fleck was overly apparent. Perhaps assisted by the success of O Brother, Where Art Thou?, which brought traditional roots music to a george Ellery Hale new collegiate audience, Nickel Creek became a slow-building polish off; by other 2002, it had done for gold, climbed into the country Top 20, and earned a Grammy nomination for Best Bluegrass Album. Meanwhile, Sean released his solo debut, Allow It Fall, in 2001, and Thile followed suit with Not All Who Wander Are Lost. Nickel Creek released their sophomore mend, This Side, in 2002; it debuted in the Top 20 of the pop charts and went all the fashion to number iI on the area listings. Even more eclectic than its forerunner, the Krauss-produced album off indie rock'n'roll fans' heads with a cover of Pavement's "Spittle on a Stranger." This Side north Korean won a Grammy for Best Contemporary Folk Album in early 2003, subsequently which Sean issued his endorsement solo album, 26 Miles. In 2005, the chemical mathematical group worked with producers Tony Berg and Eric Valentine (the latter had worked with Smash Mouth and Queens of the Stone Age) to produce Why Should the Fire Die?, a dark and introspective accumulation of new material that ground the trinity steering even farther out from their bluegrass beginnings. In mid-2006, Nickel Creek announced it would be pickings an indefinite hiatus following a scheduled circuit of duty the conterminous year, so its members could centralize on solo ferment.
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